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KMID : 0931320220220030222
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대한상부위장관.헬리코박터학회지
2022 Volume.22 No. 3 p.222 ~ p.230
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Low Serum Level of High-density Lipoprotein Cholesterol Is Associated with Gastric Cancer Regardless of Sex and Tumor Stage
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Nam Su-Youn
Jeong Ji-Hyeon
Lee Won-Kee
Jeon Seong-Woo
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Abstract
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Background/Aims: HDL cholesterol (HDL-C) may have anti-tumor effects; however, the effects remain unclear. Thus, this study aimed to investigate sex- and tumor stage-specific association of hyperglycemia and HDL-C with gastric cancer.
Materials and Methods: We used the National Health Insurance Service data. All participants underwent gastric cancer screening between January and December 2011. Hyperglycemia and HDL-C levels were categorized according to the World Health Organization guideline and Adult Treatment Panel III. Adjusted regression analysis was performed using ORs and 95% CIs.
Results: Gastric cancer was detected in 10,417 of 5.49 million individuals (2.43 million men). Hyperglycemia (OR, 1.28; 95% CI, 1.20~1.36) and low HDL-C levels (OR, 1.41; 95% CI, 1.35~1.48) were associated with gastric cancer. In the sub-analysis by sex, hyperglycemia (≥126 mg/dL) was associated with gastric cancer in both men (OR, 1.26; 95% CI, 1.18~1.36) and women (OR, 1.32; 95% CI, 1.17~1.49). Low HDL-C levels were associated with gastric cancer in both men (OR, 1.49; 95% CI, 1.40~1.58) and women (OR, 1.32; 95% CI, 1.27~1.42). In the sub-analysis by tumor stage, hyperglycemia was associated with both early (OR, 1.14; 95% CI, 1.08~1.20) and advanced gastric cancer (OR, 1.39; 95% CI, 1.26~1.55). Low HDL-C levels were also associated with early (OR, 1.34; 95% CI, 1.27~1.41) and advanced gastric cancer (OR, 1.92; 95% CI, 1.74~2.13).
Conclusions: Hyperglycemia and low HDL-C levels are consistently associated with gastric cancer regardless of sex or tumor stage.
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KEYWORD
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Body mass index, Stomach neoplasms, High density lipoprotein, Sex
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